1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene
P-tolyl sulfoxide
CAS: 1774-35-2
Molecular Formula: C14H14OS
1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene - Names and Identifiers
| Name | P-tolyl sulfoxide |
| Synonyms | Tolylsulfoxide Ditolyl sulfoxide P-tolyl sulfoxide Ditolyl sulphoxide 4,4'-Ditolyl sulfoxide bis(p-tolyl)sulphoxide 1,1'-sulfinylbis-p-toluen 4,4'-Dimethyldiphenylsulfoxide 4,4-Dimethyl diphenyl sulfoxide 4,4'-DIMETHYLDIPHENYLSULPHOXIDE 4,4'-DIMETHYL DIPHENYL SULFOXIDE 1,1'-sulfinylbis(4-methyl-benzen 1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene TOLYL SULPHOXIDE1,1'-sulfinylbis(4-methylbenzene) |
| CAS | 1774-35-2 |
| EINECS | 217-203-7 |
| InChI | InChI=1/C14H14OS/c1-11-3-7-13(8-4-11)16(15)14-9-5-12(2)6-10-14/h3-10H,1-2H3 |
1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene - Physico-chemical Properties
| Molecular Formula | C14H14OS |
| Molar Mass | 230.33 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Melting Point | 94-96 °C (lit.) |
| Boling Point | 378.3±31.0 °C(Predicted) |
| Flash Point | 182.6°C |
| Vapor Presure | 1.39E-05mmHg at 25°C |
| Storage Condition | Room Temprature |
| Refractive Index | 1.641 |
| MDL | MFCD00008546 |
1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene - Risk and Safety
| WGK Germany | 3 |
| RTECS | XT4810000 |
1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene - Reference Information
| use | 4,4 '-xylene sulfoxide is a sulfoxide compound. Representative listed drugs containing sulfoxide skeleton structure such as esomeprazole (A.Aktiebolag,US5877192A,1998) for treating intestines and stomach and modafinil (L.L.Lafon,US4927855A,1990) for treating narcolepsy and anorexia. Due to its structural diversity and remarkable biological functions, the synthesis of sulfoxide has attracted extensive attention from organic synthetic chemists and pharmacists. In addition, sulfoxide compounds also have important biological activities. By modifying the structure of sulfoxide compounds, their pharmacodynamic activities can be improved, such as anti-ulcer, anti-virus, anti-HIV-1, anti-tumor, etc. In the field of pesticides, sulfoxides have the advantages of less dosage and low pollution as fungicides and herbicides. Sulfoxide compounds contain semi-polar groups and are a soft alkali neutral extractant. They have special affinity for precious metals of soft acids, so they have high extraction rate and good selectivity for precious metals. At the same time, sulfoxide is an important component of many natural products and pharmaceutical intermediates. Therefore, it is of great significance to develop efficient and fast synthesis of sulfoxide, and it is also a hot research field. |
| preparation | in a 15mL reaction tube, p-methyl phenylazo methyl sulfone 1b(0.6mmol), p-methyl thiophenol 2b(0.2mmol), acetonitrile 1mL and water 1mL are sequentially added, mixed evenly, and then stirred for 16h at a reaction temperature of 25 degrees under the irradiation of 3W blue LED lamp. TLC is used to detect until the reaction is completed, and then ethyl acetate is added for extraction, 3mL each time, 3 times of extraction, and the extraction liquid is combined. After the extraction liquid is dried by anhydrous sodium sulfate, the extraction liquid is subjected to vacuum (0.08Mpa) The reduced pressure is concentrated to a solvent-free product to obtain a crude product, and then rinsed with a mixed eluent of petroleum ether and ethyl acetate with a volume ratio of 5:1, and the silica gel column rapid column chromatography is used to obtain 4,4 '-xylene sulfoxide, 32.2mg of yellow oily solid with 70% yield. |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
Last Update：2024-04-09 02:00:03
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